Journal Articles

Psychology-based Unified Dynamic Framework for Curriculum Learning

Guangyu Meng, Qingkai Zeng, John P. Lalor, Hong Yu

Computational Linguistics Journal, 2025

A psychology-based curriculum learning framework that applies Item Response Theory to artificial crowds for model-independent difficulty quantification. Demonstrated effectiveness on both classification and generation tasks, achieving 69.68% faster training and 75.48% speedup over state-of-the-art methods on large language model fine-tuning.

Cell Instance Segmentation: The Devil Is in the Boundaries

Peixian Liang, Yifan Ding, Yizhe Zhang, Jianxu Chen, Hao Zheng, Hongxiao Wang, Yejia Zhang, Guangyu Meng, Tim Weninger, Michael Niemier, X. Sharon Hu, Danny Z. Chen

IEEE Transactions on Medical Imaging (TMI), 2025

Ceb, a boundary-aware approach to cell instance segmentation that clusters foreground pixels by classifying cell boundaries instead of relying on pixel-wise objectives, which often discard geometric properties such as shape, curvature, and convexity. Starting from semantic segmentation probability maps, Ceb generates candidate boundaries with a revised Watershed algorithm, encodes each as a novel "boundary signature," and trains a lightweight CNN to separate true from false boundaries; a temporal-consistency extension further improves performance on cell video datasets. Across six public datasets, Ceb consistently outperforms existing foreground pixel-clustering methods and is competitive with or better than state-of-the-art cell instance segmentation methods.

Efficient Approximation of Earth Mover's Distance Based on Nearest Neighbor Search

Guangyu Meng, Ruyu Zhou, Liu Liu, Peixian Liang, Fang Liu, Danny Z. Chen, Michael Niemier, X. Sharon Hu

IEEE Transactions on Multimedia (TMM), 2025

A GPU-accelerated Nearest Neighbor Search approximation algorithm achieving 44× to 135× speedup over exact Earth Mover's Distance computation while maintaining superior accuracy (91.88% on 20news, 93.24% on Amazon reviews). Includes comprehensive theoretical analysis of time complexity and error bounds, enabling scalable optimal transport for large-scale computer vision applications.

Conference Papers

TopoAgent: An Agentic Framework for Automated Topology Learning in Medical Imaging

Guangyu Meng, Pengfei Gu, Xueyang Li, Yiyu Shi, Erin W. Chambers, Danny Z. Chen

European Conference on Computer Vision (ECCV), 2026

The first LLM-based agentic framework for automated topological descriptor selection in medical imaging. Operating through a Perception-Reasoning-Action-Reflection loop with 21 domain-specific tools and dual memory, TopoAgent selects from 15 topological descriptors, configures parameters, and returns features with a full reasoning trace. On TopoBenchmark (113,182 samples, 5 morphological categories), it achieves 68.21% balanced accuracy, outperforming the strongest baseline by 9.32% and general-purpose LLMs by over 21%.

TopoCL: Topology-Enhanced Contrastive Learning for Medical Image Analysis

Guangyu Meng, Pengfei Gu, John P. Lalor, Peixian Liang, Erin W. Chambers, Danny Z. Chen

IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR), 2026

A universal framework that demonstrates consistent accuracy improvements averaging +3.26% with strong statistical significance (80% of comparisons with p<0.001) across five state-of-the-art contrastive learning methods (SimCLR, MoCo-v3, BYOL, DINO, and Barlow Twins) on five medical imaging datasets. Features topology-aware augmentations, a Hierarchical Topology Encoder, and an adaptive mixture-of-experts fusion module.

Early Forecasting of the Impact of Traffic Accidents Using a Single Shot Observation

Guangyu Meng, Qisheng Jiang, Kaiqun Fu, Beiyu Lin, Chang-Tien Lu, Zhiqian Chen

SIAM International Conference on Data Mining (SDM), 2022

Novel graph-based approach for predicting traffic accident impact using single snapshot observations, leveraging abrupt signal modeling in graph neural networks.

Under Review

VTRL-Med: Vision-Topology Reinforced Learning for Medical Image Clustering

Guangyu Meng, Pengfei Gu, John P. Lalor, Peixian Liang, Erin W. Chambers, Danny Z. Chen

Under review at WACV 2027

A novel visual-structural and topology-aware framework that achieves state-of-the-art performance with 81.51% average accuracy across 13 medical benchmarks, representing a 4.48% improvement over existing baselines while nearly matching supervised methods in a fully unsupervised setting. The framework adapts SAM with mask-based structural priors and persistent homology features to enable anatomically consistent clustering.

Provably Stable Reeb Graph Comparison via Gromov-Wasserstein Distance

Guangyu Meng, Erin W. Chambers

Under review at Journal of Applied and Computational Topology

A stable algorithmic framework for comparing Reeb graphs using Gromov-Wasserstein distance with persistence images, accompanied by rigorous theoretical stability proofs under scalar field perturbations. This work provides theoretical guarantees for topological shape analysis and comparison in computational geometry applications.

MS-COOT: Comparing Morse-Smale Complexes with Co-Optimal Transport

Guangyu Meng, Mingzhe Li, Erin W. Chambers

Under review at IEEE Transactions on Visualization and Computer Graphics (TVCG)

A framework for comparing Morse-Smale complexes by representing them as attributed hypergraphs and applying co-optimal transport with a type-aware penalty to jointly align critical points and their connectivity. Evaluated on scientific visualization datasets including Vortex Street, Ionization Front, Heated Cylinder, and Viscous Finger, enabling structure-aware comparison of scalar field topology.